Yao Jian-wen
2012
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Journal
Journal of Yantai University
Abstract
The intermediate methyl 4-chloropicolinate(4) is prepared from picolinic acid(2) as a starting material by chloration and esterification.Its amidation afford 4-chloro-N-methylpicolinamide(5) which is converted into key intermediate 4-(4-aminophenoxy)-N-methylpicolinamide(6) by aromatic nucleophilic substitution with 4-aminophenol.4-chloro-3-(trifluoromethyl)phenylisocyanate(8) is obtained from 4-chloro-3-trifluoromethylaniline(7) by isocyanation with triphosgene.The synthesis of title compound is completed by the condensation of intermediate(6) with(8).This process has the features of cheap material,simple operation,high yield and green chemistry.