D. Hui
2003
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Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To improve the synthetic procedure of bromomethyl cyclobutane.Method Cyclobutyl formic acid(2),prepared from diethyl malonate and trimethylene chlorobromide as starting materials via phase transfer catalyzed ring closure,hydrolysis,decarboxylation in a one pot procedure,was subjected to reduction,tosylation and bromination to afford bromomethyl cyclobutane(1)with high purity.Result and Condusion The overall yield was 41%.This process has advantages of mild reaction conditions,convenient work up,and is suitable for industrial production.