Ding Fen
2014
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Journal
Fine chemicals
Abstract
This paper is aimed at optimizing and improving the synthesis route of cetirizine hydrochloride. In the new synthesis route,chlorobenzene and benzoyl chloride were used as starting materials to produce the final product through Friedel-Crafts reaction,carbonyl reductive reaction, chlorination,and nucleophilic substitution. Compared with the original synthesis route,this synthesis route eliminated one reaction step and reduced the cost of raw materials. The total yield of cetirizine hydrochloride was increased from 20. 9% to 24. 87%. The structure of the product was characterized by means of IR,1HNMR and MS.