Li Deng-ke
2009
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Journal
Fine Chemical Intermediates
Abstract
The title compound was synthesized in 95% yield from ethyl 7-chloro-5-oxo-1-tosyl-2,3,4,5-tetrahydro-1H-benzo[b] azepine-4-carboxylate in one-step reaction in sulfuric acid.The effects of the concentration of sulfuric acid and the ratio of the reactants were studied.The synthetic process has advantages of simple operation,convenient manipulation and scalable.