V. Tararov, R. Kadyrov, Z. Kadyrova
Feb 13, 2002
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0
Influential Citations
15
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Journal
Tetrahedron-asymmetry
Abstract
A facile multigram scale preparation of (1R,3S,4S)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid via stereoselective synthesis of the corresponding α-amino ester hydrochloride is detailed. Hitherto applied protocols for the synthesis of this cyclic proline analogue involving a tedious chromatographic purification step could thus be considerably improved upon. The specific rotation of the α-amino acid reported in the literature has been revised.