Young-ho Kim, V. Grubliauskas, O. M. Friedman
Jun 1, 1972
Citations
0
Influential Citations
7
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A more practical synthesis of homopteroic and homofolic acids involving condensation of 2,4,5-triamino-6(1H)pyrimidinone (3) with 1-acetoxy-4-[N-acetyl-(p-carbethoxyphenyl)amino]-2-butanone (7) is described. The biological activities of homofolic (1-b) and homopteroic (2-b) acids were compared and found to be identical with the activities of these products prepared by the unambiguous route.