Josiah W. Johnson, Kyle W. Cain, Tori B. Dunlap
Nov 30, 2018
Citations
0
Influential Citations
1
Citations
Journal
ACS Omega
Abstract
An improved and high yielding three-step synthesis for the production of 2-trifluoromethyl-10-aminopropylphenothiazine (TAPP) using less hazardous and more inexpensive reagents, its coupling to Sepharose-4B resin, and its ability to purify calmodulin are described. The overall yield of TAPP, starting with 3-aminopropyl bromide hydrobromide and 2-(trifluoromethyl)phenothiazine, was 96%.