Yonghua Lei, Tianhan Hu, Mingyang Hu
Aug 26, 2015
Citations
0
Influential Citations
4
Citations
Journal
Tetrahedron Letters
Abstract
An improved and scalable synthetic method of N-(5-(4-cyanophenyl)-3-hydroxypicolinoyl)glycine, a promising inhibitor of PHD2, is described. The optimized route staring from commercially available 5-bromo-3-nitropicolinonitrile takes only five chemical steps and has a dramatically increased total yield of 37.6% without chromatographic purifications.