Ren Li-jun
2008
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Journal
Chinese Journal of New Drugs
Abstract
Obiective: To synthesize 4-butyrylamino-3-methyl-5-nitrobenzoate.Method: The methyl 4-butyrylamino-3-methylbenzoate was prepared from methyl 4-amino-3-methylbenzoate and butyryl chloride in chloroform,then the reaction solution was dropped to the 95% fuming nitric acid at-10℃~-5℃.Results: The methyl 4-butyrylamino-3-methyl-5-nitrobenzoate was prepared with overall yield of 88% using this improved synthetic procedure.Conclusion: The improved nitration method has a remarkable virtue of high yield and efficiency,and low cost;it can be used to produce continuously.