Dongfeng Zhang, Peng Li, Zi-yun Lin
Mar 1, 2014
Citations
0
Influential Citations
2
Citations
Journal
Chinese Chemical Letters
Abstract
Abstract An improved and efficient method for synthesis of (lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptane (1) from trans-4-hydroxy- l -proline was developed. Using benzyloxycarbonyl (Cbz) as protection group of amine, the reactions were in mild conditions, and the title compound 1 was accomplished in six steps in overall yield of 70%.