Jambula Mukunda Reddy, G. Prasad, V. Raju
Feb 15, 2007
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Influential Citations
16
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Journal
Organic Process Research & Development
Abstract
An economical new process route has been developed for the large-scale synthesis of memantine hydrochloride (1) an anti-Alzheimer's drug. The procedure involves the conversion of 1,3-dimethyl adamantane (2) to formamide intermediate 8 as a key step, followed by hydrolysis to (1-amino-3,5-dimethyl adamantane) hydrochloride (1) in good yield.