Zhuang Xiong, Wang Hui-hai
2006
Citations
0
Influential Citations
0
Citations
Journal
Progress in Pharmaceutical Sciences
Abstract
Objective:To improve the synthesis method of cis-hexahydroisoindoline,an important intermediate of mitiglinide.Methods:Cis-hexahydrophthalic anhydride reacted with urea to obtain cis-hexahydrophthalimide,followed by reduction reaction with lithium-aluminum hydride to remove the two carbonyls,to obtain target compound.Results:The target compound was synthesized,its purity was more than 98% and the total yield was 56.3%.Its structure was confirmed by(()~(1)HNMR) and ESI-MS.Conclusion:The materials used for the improved synthesis are easily obtained,the reaction conditions are very moderate,and the product purity and yield are increased in improved synthesis.This synthesis method is suitable for industry.