Wu Yu
2005
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Journal
Chinese Journal of Pharmaceuticals
Abstract
Methyl 3-oxo-4-androstene-17β-carboxylate was prepared from pregnenolone acetate by bromoform reac-tion and esterification to give methyl 3β-hydroxy-5-androstene-17β-carboxylate, which subjected to Oppenauer oxidation in presence of aluminium isopropoxide using 2-nitrobenzaldehyde as hydrogen acceptor in toluene at 95℃ for 2h. The overall yield was 71%.