I. Novakov, B. Orlinson, R. V. Brunilin
Nov 17, 2011
Citations
0
Influential Citations
5
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
We describe here a new and efficient method for synthesis of N-(3-phenyl[2.2.1]bicyclohept-2-yl)-N-ethylamine hydrochloride (Fencamfamine), based on the reduction of trans-5-nitro-6-phenylbicyclo[2.2.1]hept-2-ene with Raney alloy mixed with aqueous NaOH and tetrahydrofuran followed by N-alkylation of the resulting product with 95% ethanol in the presence of skeletal nickel.