Mu Zi-qi
2012
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Journal
Qilu Pharmaceutical Affairs
Abstract
Objective To improve synthetic method of the key intermediate of olmesartan medoxomil.Methods 4-(1-hydroxy-1-methyl-ethyl)-2-propyl-1-[2'-(triphenylmethyl tetrazole-5-yl)biphenyl-4-methyl]imidazole-5-carboxylic acid ethyl ester was synthesized from 4-(1-hydroxy-1-methyl-ethyl)-2-propylimidazole-5-carboxylate ethyl ester through condensation with 4-[2-(2-(triphenylmethyl)tetrazole-5-yl)phenyl]benzyl bromide.Results and Conclusion The optimized synthesis method was simple with 55% yield of the intermediate and the quality was good.