Chen Hong-bo
2013
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Journal
Fine Chemical Intermediates
Abstract
Pipecuronium bromide(1) was synthesized in overall yield of 19.3% in several steps and its structure was characterized with 1H NMR and MS spectra.In the synthesis process of the key intermediate 2β,16β-bis-(4methyl-piperazinyl)-3α-hydroxy-17-keto-5α-androst steranes(5),the bromination was combined with the ring-opening addition in one step thus effectively reduced the production costs.This improved process is simple and conducive to industrial production.