Liang Liwei
2010
Citations
0
Influential Citations
3
Citations
Journal
The Chinese Journal of Modern Applied Pharmacy
Abstract
OBJECTIVE To synthesize the title compound and improve process to make it suitable for industrial production,and increase yield.METHODS Cefathiamidine was synthesized from 7-ACA as starting material,acylated by bromoacetyl bromide at C-7 position in a low temperature and alkaline condition,and then condensed by side chain diisopropylthiourea.RESULTS The overall yield was increased from 45% to 62%,the structure of product was confirmed by IR,MS,and 1H-NMR.CONCLUSION The improved process was greatly simplified,with a total yield improved,and suitable for industrial production.