Wangze Song
2001
Citations
0
Influential Citations
1
Citations
Journal
Chinese Journal of Synthetic Chemistry
Abstract
An improved synthesis of flutamide using 3 trifluoromethyanilineas a starting material is described . Treatment of 3 trifluoromethylaniline with 2 methylprop inonyl chloride in the presence of anhydrous sodium bicarbonate as the hydrogen chloride acceptor gave 2 methyl N [(3 trifluoro methyl)phenyl]propionamide, which was nitrated at -2℃ with a fuming nitro sulfuric acid mixture to yield corresponding 2 methyl N [(4 nitro 3 trifluoromethyl)phenyl]propanamide.