X. Ping
2003
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Journal
Chinese Journal of Medicinal Chemistry
Abstract
Aim To research the new synthesis of trimetazidine hydrochloride.Methods 1,2,3-trimethoxybenzene was used as the starting material,which was first chloromethylated to produce(2,3,4-thimethoxy)benzyl chloride(Ⅰ ]),followed by the condensation with piperazine hexahydrate,and then saltforming with hydrochloric acid to yield 1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride(),followed by the condensation with piperazine hexahydrate,and then saltforming with hydrochloric acid to yield 1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride(Ⅱ ],trimetazidine hydrochloride).,trimetazidine hydrochloride).Results A new synthetic route of trimetazidine hydrochloride was designed and carried out.Conclusion This improved synthesis can be used industrially with a lower cost,fewer steps,simpler operation,and mild reaction conditions.