Y. Yuasa, Toru Watanabe, A. Nagakura
1992
Citations
0
Influential Citations
8
Citations
Journal
Tetrahedron
Abstract
Abstract (S)-Aspartyl-(7,7-dimenthylnorborn-2R-yl)-(S)-alanine methyl ester ( 1 ) was synthesized in nine steps from (+)-α-fenchyl alcohol ( 3 ) as a chiral synthon. Crucial steps for controlling the side-chain stereochemistry of 1 , required for the manifestation of sweetness, were the catalytic hydroformylation of the olefin 4 and the enzymatic resolution of the racemic amino acid 9 using acylase I.