Ge Meng, Meilin Zheng, Mei Wang
Jan 1, 2011
Citations
0
Influential Citations
7
Citations
Journal
Organic Preparations and Procedures International
Abstract
2,4-Dimethylpyrrole (1) is a very important intermediate in the synthesis of fluorescent molecules (such as BODIPY),1,2 the new tyrosine kinase inhibitor (such as sunitinib),3–5 anti-inflammatory/analgesic agent6 and so forth. The traditional synthetic methods of 1 usually involved several steps including the construction of the pyrroles skeleton by the Knorr reaction using 1,3-diketones,7 and by oximation of either acetoacetic esters or malonates via a dissolving-zinc reduction and subsequent hydrolysis, acidification and decarboxylation (Scheme 1).8,9