Pan Wen-zhe
2010
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Journal
China Pharmacy
Abstract
OBJECTIVE:To establish a mercury-free perchloric acid potentiometric titration method for the content determination of rocuronium bromide.METHODS:Mettler DG113-SC was used as the composite electrode.The potentiometric titration was performed with glacial acetic acid and acetic anhydride as solvents and perchloric acid(0.1 mol·L-1) as titration.The method was compared with that stated in European Pharmacopeia.RESULTS:The linear range of rocuronium bromide was 0.150 1~0.401 3 g(r=0.999 9) with an average recovery within 99.90%~99.98%.The detection limit was 1.71 mg.There was no difference between results detected by two methods.CONCLUSION:The method is simple,sensitive and accurate for the content determination of rocuronium bromide.