V. M. Tursin, L. G. Chebotareva, A. M. Yurkevich
Dec 1, 1975
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Journal
Pharmaceutical Chemistry Journal
Abstract
In this connection we studied various ways of synthesizing them [3]. A description of a modified method of obtaining lipoic acid amide, based on using the ester of 6,8-dichlorooctanoic acid (I) [4], is given in this paper. The ester is transformed by reaction with an aqueous methanol solution of ammonia to the amide of 6,8-dichlorooctanoic acid (II) and the amide of lipoic acid (III) is obtained from the latter and sodium disulfide.