Zhao Xiang-kui
2009
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Journal
Fine Chemical Intermediates
Abstract
5-Fluoro-2-hydroxyacetophenone was prepared from p-aminophenol in an overall yield of 54.5%.In the first step,both groups of amino and hydroxyl in p-aminophenol were esterificated in one step,followed by Fries rearrangement in the presence of AlCl3/ NaCl.The product was then hydrolyzed and fluorin diazotized to give the title product.