Liu Jingfen, B. Li, S. Zhou
2001
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Journal
The Chinese Journal of Modern Applied Pharmacy
Abstract
OBJECTIVE:To simplify the method of synthesizing p fluorobenzylamine and low the cost of raw material. METHOD:p Fluorobenzylamine, which is the intermediate compound of some medicine, was synthesized by 3 steps with p Nitrobenzoic acid as starting material. The 3 steps were fluorization, acylation and reduction. RESULTS:The overall yield was 30.43%. CONCLUSION:The process was simple and safe. The raw material was abundant and its cost was low.