Wu Chun-le
2015
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Journal
Fine and Specialty Chemicals
Abstract
The synthetic process of 2-mercapto-5-methoxy-1 H-benzimidazole which is the intermediate of Omeprazole was introduced.4-methoxy-2-nitrophenyl amine was obtained using p-anisidine as the raw material by protecting of amino-group,nitrifying,hydrolysizing acylamide,and than with catalytic hydrogenation and cyclizating,to synthesize 2-mercapto-5-methoxy-1 H-benzimidazole in the end.The synthesis method is improved,has a more high yield and can be used for industry.