A. Cipiciani, M. Cittadini, F. Fringuelli
Jul 2, 1998
Citations
0
Influential Citations
21
Citations
Journal
Tetrahedron
Abstract
Abstract Racemic methyl 2-(2,4-dichlorophenoxy)propionate (±)-1, was subjected to hydrolysis in water and in a series of two-phase aqueous organic media in the presence of Candida rugosa lipase (CRL). The biocatalytic material used was the commercial preparation and enzyme purified by using different procedures. The (+)-R- and (−)-S-2-(2,4-dichlorophenoxy)propionic acids (3) were obtained in excellent yield and high enantiomeric excess when the hydrolysis of (±)-1 was performed in water/benzene in the presence of 2-propanol treated CRL. The kinetic resolution of (±)-1 was scaled-up.