Xiang Hong-lin
2006
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0
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Journal
Journal of Hunan Normal University
Abstract
Objective To improve the synthesis of tropisetron hydrochlorride.Methods tropisetron hydrochloride was synthesized from indol-3-yl carboxylic acid by chlorination and condensation with tropic alcohol lithium,then salt formation with hydrochlororic acid.Results Chemical structure of tropisetron hydrochlorride was confirmed by element analysis,IR and 1HNMR etc,the overall yield was 52.8%.Cnnclusion The process was simplified,improved and practice in industrialize.