V. Krishnamurthy, B. Braganca
Oct 7, 1961
Citations
0
Influential Citations
2
Citations
Journal
Nature
Abstract
A-METHOPTERIN (4-amino-N10-methyl pteroyl glutamic acid) inhibits the growth of certain tumours1 as well as of many folic acid dependent microorganisms2. It is a powerful inhibitor of enzyme systems reducing folic acid to tetrahydrofolic acid3. Recent investigations4,5 have shown that A-methopterin inhibits acetylation of aromatic amines. Small quantities of A-methopterin have been found to decrease considerably the urinary excretion in mice of the acetylated aromatic amine formed from injected folic acid (unpublished results). Evidence presented here shows that A-methopterin is inactivated by the acetylating enzyme system of pigeon liver.