I. A. Rose, E. O'Connell
Dec 10, 1969
Citations
0
Influential Citations
50
Citations
Journal
The Journal of biological chemistry
Abstract
Abstract Glycidol-P is shown to inactivate muscle triose-P isomerase and muscle enolase. Both inactivations show saturation kinetics and protection by substrate or competitive inhibitor. Labeling of the proteins by 1 molecule of glycidol-P per catalytic subunit results in complete loss of enzymatic activity. Both labeled proteins respond to alkali and H2NOH treatment with liberation of all radioactivity, indicating that formation of esters of glycerol-P caused the inactivations.