D. Shinkuma, T. Hamaguchi, K. Kitajima
1981
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Journal
Japanese Journal of Hospital Pharmacy
Abstract
Incompatibility of clindamycin palmitate hydrochloride dry syrup (CLDM-P·EHCl-DS) in various internal solutions was studied. Above pH 4.1, hydrochloride was dissociated from clindamycin palmitate, and a white turbidity was produced. CLDM-P·HCl-DS was dissolved in 14 different solutions, where 10 gave a change in appearance. When stored below 5°, CLDM-P·EHCl-DS solution often turned to a white gel.