Li Min-r
2015
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Journal
China Practical Medicine
Abstract
Objective To investigate the incompatibility between cefamandole nafate for injection and omeprazole sodium for injection. Methods High performance liquid chromatography(HPLC) was applied to detect changes of external appearance, relative amount and p H of cefamandole nafate and omeprazole sodium in different time points during 6 h under 4, 25, and 30℃. Results After 6 h under indoor temperature(25 and 30℃), the solutions had obvious changes in external appearance, clarity, and p H. Contents of cefamandole nafate and omeprazole sodium were remarkably decreased. Conclusion Cefamandole nafate for injection is incompatible with omeprazole sodium for injection, and they should be applied separately.