T. R. Bates, H. A. Rosenberg, A. V. Tembo
Dec 1, 1973
Citations
0
Influential Citations
18
Citations
Journal
Journal of pharmaceutical sciences
Abstract
Abstract Nitrofurantoin, l-[(5-nitrofurfurylidene)amino] hydantoin, is an antibacterial agent used clinically to treat specific urinary tract infections. Physiocochemically, the drug is a weak acid (pKa 7.2) possessing relatively low aqueous solubility characteristics at pH values normally encountered in the various segments of the GI tract of man. As a result, it is not surprising that the drug displays a particle-size dependence in its dissolution rate (1) and rate and extent of absorption (bioavailability) in man (1–4).