David J. Slade, N. Pelz, W. Bodnar
Jul 21, 2009
Citations
0
Influential Citations
58
Citations
Journal
The Journal of organic chemistry
Abstract
Indazoles are unselectively protected under strongly basic conditions to give a mixture at N-1 and N-2. Under mildly acidic conditions, regioselective protection at N-2 takes place. Thermodynamic conditions lead to regioselective protection at N-1. This trend applies to various substituted indazoles. Protected 5-bromoindazoles participate in Buchwald reactions with a range of amines to generate novel derivatives.