F. L. Faraj, Hamid Khaledi, H. Karimian
May 1, 2017
Citations
0
Influential Citations
5
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Dimerization of 2-(diformylmethylene)-3,3-dimethylindole by the action of tosyl chloride (TsCl) led to the creation of an epoxy-[1,5]-diazocine bicycle. The structure of the molecule resembles that of the naturally occurring C-curarine-I. The molecule shows significant cytotoxicity against cancer lines MCF-7 and MDA-MB-231, but not toward the normal cell line CCD-841. A series of substituted 2-(diformylmethylene)-3,3-dimethylindoles was accordingly dimerized, and the products were studied for their cytotoxic activities.