J. Bentley, D. Adams, D. Bebbington
May 3, 2004
Citations
0
Influential Citations
34
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand binding data for all of the compounds at 5-HT(2) receptor subtypes are reported. A number of compounds were found to reduce food intake in rats after oral administration.