B. W. Turnpenny, K. L. Hyman, S. Chemler
Aug 27, 2012
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53
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Journal
Organometallics
Abstract
An enantioselective copper-catalyzed hydroamination / cyclization of N-sulfonyl-2-allylanilines for the synthesis of chiral 2-methylindolines is reported. Chiral 2-methylindolines are important subunits in drugs and bioactive compounds. This method provides chiral N-sulfonyl-2-methyl indolines in up to 90% ee.