R. Werner, Lance F. Thorpe, W. Reuter
Sep 1, 1976
Citations
2
Influential Citations
85
Citations
Quality indicators
Journal
European journal of biochemistry
Abstract
Indolmycin specifically prevents the formation of tryptophanyl-tRNA in a prokaryotic system in vitro using Escherichia coli enzymes. However, the drug has little effect in an eukaryotic system in vitro (rat liver enzymes). Analysis of the type of inhibition revealed that indolmycin competes with tryptophan as a pure competitive inhibitor of prokaryotic tryptophanyl-tRNA ligase.