J. Bertram, A. Craig
Dec 1, 1972
Citations
5
Influential Citations
134
Citations
Quality indicators
Journal
European journal of cancer
Abstract
Abstract Butyl-( 4 -hydroxybutyl) nitrosamine (BBN) has been shown to be a highly potent and specific bladder carcinogen when administered continuously in the drinking water to 50 male and 50 female C 57 BL/ 6 mice. Bladder carcinomas were found in all mice reaching autopsy, other toxic effects were absent. Metastatic spread had occurred in 13 mice. In spite of an identical dosage of 35 mg/kg/day BBN, males developed bladder tumours significantly earlier than did females ( 190 and 253 days respectively). Early changes in the bladder epithelium were also delayed in the female. This sex difference in susceptibility to tumour induction can be abolished by castrating males or conversely by treating females with testosterone. Testosterone restores the tumour-induction time in castrated males to control values. Phenobarbitone, when given concurrently with the carcinogen, had no effect on the induction of tumours by BBN but partially protected mice against the carcinogenic effects of dibutylnitrosamine.