Fang Jia
1999
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Quality indicators
Journal
The Chinese Journal of Clinical Pharmacology
Abstract
8-Chloroadenosine (8-Cl-Ado) is a new compound that is able to inhibit the growth of a wide variety of cancer cell types in vitro and in vivo. In this study we have found that differentiation of human acute myeloblastic leukemia(M2)cell line HL-60 can be induced by 8-Cl-Ado, FCM-DNA analysis showed that 8-Cl-Ado caused a block in G0/G1 phase of HL-60 and Molt-4 lymphoblast cell line. 8-Cl-Ado induced dose and time-dependent apoptosis in Molt-4 cells , but apoptosis was not observed in HL-60 cells treated with 8-Cl-Ado. These results suggest that induction of differentiation and apoptosis by 8-Cl-Ado is cell type specificity,and there is no causality between differentiation and apoptosis.