M. Makishima, Y. Honma, M. Hozumi
Aug 5, 1991
Citations
3
Influential Citations
30
Citations
Quality indicators
Journal
FEBS Letters
Abstract
Inhibitors of myosin light chain kinase, 1‐(5‐chloronaphthalene‐1‐sulfonyl)‐1H‐hexanydro‐1,4‐diazepine hydrochloride (ML‐9) and 1‐(5‐iodonaph‐thalene‐1‐sulfonyl)‐1 H‐hexahydro‐1,4‐diazepine hydrochloride (ML‐7), induced Nitroblue tetrazolium reducing activity, lysozyme activity and morphological maturation of human monoblastic U937, THP‐1 and promyelocytic HL‐60 cells, but not of erythroblastic K562 cells. However, three analogs of ML‐9, which are an inhibitor and an activator of protein kinase C, and a calmodulin antagonist, respectively, did not induce differentiation of the cells.