Y. Ikeda, S. Horiuchi, A. Imoto
Sep 1, 1974
Citations
0
Influential Citations
8
Citations
Journal
Toxicology
Abstract
Abstract A group of 35 female Sprague-Dawley rats was fed a diet containing 5% Benzyl Violet 4B for 12 months. Another group of 35 rats served as controls. In the experimental group growth was significantly depressed and only 2 animals survived the entire experimental period. Tumours developed externally in 22 out of 35 animals of the experimental group, which included 11 animals with mammary gland carcinoma, 4 animals with squamous cell carcinoma of the skin and 7 animals with both types of tumours. Though the majority of the squamous cell carcinomas developed in the ear-duct, they also appeared in the buccal and axillary regions. The mammary gland carcinomas appeared earlier than the squamous cell carcinomas of the skin. No external tumour was observed in the control group.