M. Buiatti
Feb 1, 1968
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
Cancer research
Abstract
Summary Azauracil was found to be the only one of several analogs of nucleic acid precursors tested in these studies which is capable of inducing tumors at a very early stage during seedling development in the genetically tumor-conditioned hybrid Nicotiana glauca × N. langsdorffii . Tumor induction by 6-azauracil was shown to be reversed by simultaneous treatments with uracil and actinomycin D as well as by posttreatments. Pre-treatments with the same substances proved to be ineffective. The possible implications of the findings in view of the possible involvement of an abnormal species of RNA in the process of tumor induction by 6-azauracil are discussed.