Harnam Singh, N. Gupta, Pramod Kumar
Aug 20, 2009
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Influential Citations
26
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Journal
Organic Process Research & Development
Abstract
A new industrial process, involving only two isolation and drying steps, for 10-methoxyiminostilbene (MISB), an advance intermediate of widely prescribed antiepileptic drug, oxcarbazepine, has been developed. A salient feature of this process is the novel use of 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) to afford bromohydrin methyl ether from N-acetyliminostilbene. The byproducts of this process namely acetic acid, 5,5-dimethylhydantoin and Et3N·HBr are recyclable as well as nontoxic. This process is amenable for the large-scale production of MISB.