M. Takayama, Yoshiaki Tanaka, T. Nomura
Feb 1, 1993
Citations
0
Influential Citations
4
Citations
Journal
Rapid Communications in Mass Spectrometry
Abstract
The influence of acetylation on the formation of sodium adduct [M + Na]+ ions, under fast-atom bombardment conditions, has been investigated using monosubstituted phenol and aniline compounds. The acetylation of o-isomers, except for the nitrophenols, highly enhanced the [M + Na]+ ion formation, while m- and p-isomers showed little effect on acetylation except for p-methoxyphenol and aniline. The favorable effect of acetylation on [M + Na]+ ion formation is explained by the conformational flexibility of COAc and GNHAc functions and the carbonyl oxygen as a cation-accepting site, which are advantageous for the multisite interaction with a Na+ ion.