Lu Wei-xing
2010
Citations
0
Influential Citations
1
Citations
Quality indicators
Journal
Journal of Beijing University of Traditional Chinese Medicine
Abstract
Objective To investigate the mechanism of aralosides in antagonism of myocardial ischemia,and provide a theoretical base for it used for preventing and treating coronary heart disease(CHD).Methods All rats were randomly divided into the control group(0.9% sodium chloride solution,10 mL/kg),aralosides group(aralosides solution,0.5 g/kg) and clopidogrel group(clopidogrel solution,5 mg/kg).After intragastrical administration of drugs for 5 days respectively in all groups,the anterior descending coronary was ligated to induce ischemia for 45 minutes and then reperfused for 5 minutes.The pathological changes of myocardial tissue were observed in all groups,the expression of endocardial CD40L was detected by using immunohistochemistry,and levels of myocardial malondialdehyde(MDA) and glutathione peroxidase(GSH-PX) were detected.Results Compared with the control group,the expression of CD40L decreased(P0.05),and vigour of myocardial GSH-PX increased(P0.05) in aralosides group and clopidogrel group,but the difference was not significant statistically(P0.05).The level of myocardial MDA decreased in the aralosides group(P0.05).Conclusion Aralosides can decrease the expression of CD40L,improve the vigour of myocardial GSH-PX and reduce the level of myocardial MDA in rats with myocardial ischemia and reperfusion.