I. Efimenko, N. A. Ivanova, O. S. Erofeeva
May 3, 2009
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Journal
Russian Journal of Coordination Chemistry
Abstract
The systems Pd(II)-Cl−-HA-H2O (where HA are the conformers of 2-methylamino-1-phenylpropan-1-ol) were studied. The acid dissociation constants of the ligands HA and the resulting complexes were determined by pH-metric titration and mathematical modeling. The pH-distribution diagram of the complex species in the system containing different HA conformers was obtained. The complexes (H2A)2[PdCl4] were obtained and structurally characterized; their toxicity and radioprotective effects were estimated. The biological activity of the complexes was found to depend on both the ligand basicity and the hydrogen bonding system formed by different conformers of the ligand in the cation-anion complexes.