Wang Xuelian
2012
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Quality indicators
Journal
Chinese Journal of Neurosurgical Disease Research
Abstract
Objective To study the influence of Exelon on the cognitive function of the patients with mental disorder treated by stereotactic neurosurgery.Methods All the patients who accepted the stereotactic neurosurgery at our therapy centre during March 2008 to March 2010 and who fit in the selected standard were included in the study.All the patients were paired and divided randomly into treatment group and placebo group,with 42 in each.In the treatment group Exelon was taken from the first week post-operation to 6 months post-operation.The indices of cognitive function,life qualities and social functions were examined by mini mental state examination(MMSE),the schizophrenia quality of life scale(SQLS) and self-designed social functions scale.Results The MMSE total points,directive force and the memory of the treatment group had been significantly improved compared with the placebo group at 6 months post-operation.The social-psychological dimension and motive/energy dimension of SQLS of the treatment group were improved compared with those of the placebo group at 12 months post-operation.The improvement of the social functions of the treatment group was significantly improved compared with that of placebo group at 12 months post-operation.Conclusion Exelon can improve the cognitive function of the patients with refractory mental disorders post-operation dramatically.