Panliang Zhang, Hui Zhang, K. Tang
Feb 12, 2015
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Influential Citations
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Journal
Separation and Purification Technology
Abstract
Abstract Phenylsuccinic acid (PSA) and α-cyclohexyl-mandelic acid (α-CHMA) are dicarboxylic acid and monatomic acid, respectively, and there is effect of solution pH on multistage extraction efficiency for separation of PSA and α-CHMA enantiomers. Enantioselective liquid–liquid extraction (ELLE) of PSA and α-CHMA enantiomers with hydrophilic hydroxyphenyl- β -cyclodextrin as extractant (represented by C) was performed in a counter-current cascade of ten centrifugal contactor separators (CCSs) to investigate the influence of pH on extraction efficiency (evaluated with enantiomeric excess, ee and yield, Y ) with the HP- β -CD concentration changing from 0 to 0.1 mol/L. Experimental results show that there is a significant effect of solution pH on ee and Y for multistage extraction of PSA and α-CHMA enantiomers. Single and multistage equilibrium models of ELLE were developed to investigate the effect of solution pH on ee and Y . From experiments and simulation, it is concluded that lower pH will be helpful for obtaining higher ee and Y in both exit streams and the optimal pH of 2.5 is proposed. The above results may be very helpful to optimize the extraction efficiency and realize the large-scale production of pure enantiomers.