H. J. Hertog, C. R. Kolder, W. Combe
Sep 2, 2010
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0
Influential Citations
11
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Journal
Recueil des Travaux Chimiques des Pays-Bas
Abstract
The nitration of some mono-substituted derivatives of pyridine-N-oxide containing a bromine atom, an ethoxy- or a methyl-group in positions 2 or 3, has been investigated. When these compounds are heated With a mixture of fuming nitric acid and sulphuric acid, a nitro-group is introduced into the 4-position. It appears that the course of the nitration is not influenced by the presence of the bromine atom, the ethoxy- or methyl-group in the nucleus. A 4-nitro-compound is obtained even from 2-ethoxypyridine-N-oxide, the nitro-group entering the meta-position with respect to the strongly ortho-para directing ethoxy-group.